Lactobacillus plantarum BMD(GMNL-662)
Research Evidence
We examined if probiotic BMD could reduce bone loss associated with estrogen deficiency in ovariectomized(ovx) rats which simulate postmenopausal conditions of osteoporosis. Normal bone mass was set to 100%，and the bone mass of osteoporosis caused by OVX was set to 0%. The results show oral supplementation with probiotic BMD,100% can increase the percentage of bone mineral density, number of trabecular and trabecular area percentage up to 12~28% in the OVX rats. These data suggest a therapeutic potential for probiotic BMD in the treatment of postmenopausal osteoporosis.
◎Oral supplementation with probiotic BMD can stimulate bone formation by increasing Transforming growth factor-beta(TGF-β) and Bone morphogenetic protein (BMP). Probiotic BMD also increases the secretion of osteopontin (OPN) and osteocalcin (OCN).
◎Oral supplementation with probiotic BMD can reduce the activity of osteoclast by decreasing tartrate resistant acid phosphatase (TRAP) and type I collagen cross-linked N-telopeptides (NTX).
Potential commercial applications:
●Form: capsule, sachet, tablet
●Increase the added-value of the original product:Probiotic BMD can be added into fermentationproducts, dietary supplement, and milk (fresh/powder) to enhance the nutrition values
Targeted users:
●People who suffer from osteoporosis
●Family history of osteoporosis
●Menopause
●People who want to improve bone health